Oxamides as novel NR2B selective NMDA receptor antagonists

Gizella Barta-Szalai; István Borza; Eva Bozó; Csilla Kiss; Béla Agai; Agnes Proszenyák; György M Keseru; Anikó Gere; Sándor Kolok; Kornél Galgóczy; Csilla Horváth; Sándor Farkas; György Domány

doi:10.1016/j.bmcl.2004.05.053

Oxamides as novel NR2B selective NMDA receptor antagonists

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3953-6. doi: 10.1016/j.bmcl.2004.05.053.

Authors

Gizella Barta-Szalai¹, István Borza, Eva Bozó, Csilla Kiss, Béla Agai, Agnes Proszenyák, György M Keseru, Anikó Gere, Sándor Kolok, Kornél Galgóczy, Csilla Horváth, Sándor Farkas, György Domány

Affiliation

¹ Gedeon Richter Ltd, 10, PO Box 27, H-1475 Budapest, Hungary.

PMID: 15225705
DOI: 10.1016/j.bmcl.2004.05.053

Abstract

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.

MeSH terms

Animals
Indoles / chemical synthesis*
Indoles / pharmacology*
Mice
Models, Molecular
Molecular Structure
N-Methylaspartate / pharmacology*
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
Structure-Activity Relationship

Substances

Indoles
Receptors, N-Methyl-D-Aspartate
N-Methylaspartate